From MedicalXpress
Two day break in treatment for dialysis patients could be fatal, study finds
Patients who have kidney dialysis three times a week are more likely to be admitted to hospital or die after a two day break, according to a study by a leading kidney researcher at the University of Sheffield.
Dr James Fortheringham from the Sheffield Kidney Institute has found there is a 69 per cent increase in hospital admissions and a 22 per cent increase in deaths after a two day break in three times a week haemodialysis.
To help reduce hospital admissions and boost the survival prospects of kidney dialysis patients, Dr Fotheringham has now been awarded a five year fellowship by the National Institute of Health Research (NIHR) Clinician Scientist Award panel – one of only six researchers to be awarded the fellowship this year.
Building on this study, James will now continue his work to understand and reduce the harm being caused by the two day break.
"I'm trying to identify who it is that is getting admitted to hospital and dying after this two day break and why. Harnessing existing data including the valuable UK Renal Registry I will examine if wider use of some of the care techniques we already use here in the UK can combat the two day break problem," Dr Fotherigham said. [Read more]
PKD Research
From National Institutes of Health (NIH)
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease
Abstract
Dysregulated signaling cascades alter energy metabolism and promote cell proliferation and cyst expansion in polycystic kidney disease (PKD). Here we tested whether metabolic reprogramming towards aerobic glycolysis ("Warburg effect") plays a pathogenic role in male heterozygous Han:SPRD rats (Cy/+), a chronic progressive model of PKD. Using microarray analysis and qPCR, we found an upregulation of genes involved in glycolysis (Hk1, Hk2, Ldha) and a downregulation of genes involved in gluconeogenesis (G6pc, Lbp1) in cystic kidneys of Cy/+ rats compared with wild-type (+/+) rats. We then tested the effect of inhibiting glycolysis with 2-deoxyglucose (2DG) on renal functional loss and cyst progression in 5-week-old male Cy/+ rats. Treatment with 2DG (500 mg/kg/day) for 5 weeks resulted in significantly lower kidney weights (-27%) and 2-kidney/total-body-weight ratios (-20%) and decreased renal cyst index (-48%) compared with vehicle treatment. Cy/+ rats treated with 2DG also showed higher clearances of creatinine (1.98±0.67 vs 1.41±0.37 ml/min), BUN (0.69±0.26 vs 0.40±0.10 ml/min) and uric acid (0.38±0.20 vs 0.21±0.10 ml/min), and reduced albuminuria. Immunoblotting analysis of kidney tissues harvested from 2DG-treated Cy/+ rats showed increased phosphorylation of AMPK-α, a negative regulator of mTOR, and restoration of ERK signaling. Assessment of Ki-67 staining indicated that 2DG limits cyst progression through inhibition of epithelial cell proliferation. Taken together, our results show that targeting the glycolytic pathway may represent a promising therapeutic strategy to control cyst growth in PKD.
Brave Birmingham police worker to donate a kidney to save his brother's life
As a Birmingham police officer he is used to protecting the public - and now David Footman is preparing to help save his brother’s life.
The big-hearted Police Community Support Officer is donate a kidney to his older sibling Paul who desperately needs a transplant.
Paul, aged 39, was diagnosed with adult polycystic kidney disease 15 years ago but his condition has begun to deteriorate in recent years.
When the Birmingham chef was told that without a transplant he faced kidney failure, his brother David was quick to offer to donate one of his own kidneys in a bid to save him.
David, a dad-of-two from Kings Norton, said: “We didn’t really have a conversation, I knew he was getting worse and he needed to have this done.
“I am just grateful I am able to help. I like to make a difference as a PCSO and with it being family this was always something I was going to do.
“Hopefully, we can raise awareness of kidney disease and the importance of diagnosis.
“The force has been really supportive and I am looking forward to joining back up with the rest of the team afterwards.”
The 37-year-old will go under the knife in the next few months and said he will return to pounding the streets of Stechford and Yardley after he has had time to recuperate from the operation. [Read more]
Diamond Bar Man Celebrates Gift Of New Kidney From Wife Of An Old Coast Guard Buddy
A Diamond Bar father has gotten a new lease on life following a life-saving kidney transplant.
CBS2’s Michele Gile says his Coast Guard family stepped up in a big day.
Frank Maggelet and Patricia Lovenstein had only met twice but she had no doubt that he — a retired Coast Guard Port security chief — would get her kidney.
“Well, first of all there was no if,” she said, “I knew that it was going to happen.”
She considers him, a husband and father, like her own family.
A decade ago, her husband was his senior officer — buddies in the Coast Guard, stationed together in Boston.
A few months ago, Lovenstein — a former nurse — read on Facebook that Maggelet needed help and was in dire need of a new kidney after he developed polycystic kidney disease.
“He still has never asked me for my kidney,” she said, with a laugh, “it’s already in him. It’s a little late for that. But he’s never asked. No one ever asked me to do this.”
The transplant took place at UCI Medical Center in Orange on Tuesday.
Her left kidney now sits in his right abdomen.
Today was the first day the two got to share a private moment without family around. He was able to whisper a “thank you” to Lovenstein, grateful that the transplant came at just the right time. He was left with a kidney that barely functioned.
He learned on Thanksgiving night that he will have many more years to spend with his wife and young daughters.
“Patricia called, and the hospital called. ‘You’re a match.’ And the four of us, Thanksgiving evening, we cried,” said Maggelet, “because it was like a miracle.”
Michigan woman donates kidney to husband
GRAND RAPIDS, Mich. (WOOD) — A Michigan man celebrated his 55th birthday Thursday with a gift from his wife he’ll likely never be able to match.
Jim Sisson suffered from polycystic kidney disease, a rare genetic disorder.
His father died from complications of the disease in the 1980s.
Sisson got on a waiting list for a new kidney, joining more than 100,000 people nationwide. He was prepared for a wait that could last years.
But it turned out a match was living under the same roof – his wife Laurie.
“We’ve been very blessed. There’s so many people out there that are not this fortunate,” Laurie Sisson said.
On Monday, the transplant team at Mercy Health Saint Mary’s hospital in Grand Rapids, Michigan took one of Laurie’s kidneys and put it inside Jim.
“He kept saying he didn’t want me to of it. He wouldn’t think any less of me if I didn’t. I said, ‘God didn’t make me a match for me to be selfish and keep the kidney to myself,’” Laurie Sisson said.
“There was never once I looked back thinking I don’t want to do this.”
Laurie’s kidney worked for her husband — in more ways than one.
“I’ve been praying for a long time that we could reignite a spark. You know, when you’re married 35 years sometimes it takes a little oomph to get things where they should be,” Laurie Sisson said.
“You’ve got to be careful what you pray for.”
If there’s one message the couple wants to get out, it’s the importance of organ donation.
In Michigan alone, the waiting list for a new kidney is longer than 2,800 people. More than 350 people are waiting for a call from Mercy Health Saint Mary’s transplant program.
Jim Sisson said he was looking at a wait of up to eight years for a new kidney.
“If I would have went to Ohio, I could have got one within a year or two maybe because they have a lot more people that signed the registered donor list,” he explained.
Thursday, just three days after receiving his new kidney, Sisson celebrated his 55th birthday. His next challenge, he said, will be coming up with a gift for his wife.
“Always wanted to go on a trip,” Laurie Sisson hinted.
“Wherever she want to go now. Who’s she kidding?” her husband said.
Dr James Fortheringham from the Sheffield Kidney Institute has found there is a 69 per cent increase in hospital admissions and a 22 per cent increase in deaths after a two day break in three times a week haemodialysis.
To help reduce hospital admissions and boost the survival prospects of kidney dialysis patients, Dr Fotheringham has now been awarded a five year fellowship by the National Institute of Health Research (NIHR) Clinician Scientist Award panel – one of only six researchers to be awarded the fellowship this year.
Building on this study, James will now continue his work to understand and reduce the harm being caused by the two day break.
"I'm trying to identify who it is that is getting admitted to hospital and dying after this two day break and why. Harnessing existing data including the valuable UK Renal Registry I will examine if wider use of some of the care techniques we already use here in the UK can combat the two day break problem," Dr Fotherigham said. [Read more]
PKD Research
From National Institutes of Health (NIH)
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease
Dysregulated signaling cascades alter energy metabolism and promote cell proliferation and cyst expansion in polycystic kidney disease (PKD). Here we tested whether metabolic reprogramming towards aerobic glycolysis ("Warburg effect") plays a pathogenic role in male heterozygous Han:SPRD rats (Cy/+), a chronic progressive model of PKD. Using microarray analysis and qPCR, we found an upregulation of genes involved in glycolysis (Hk1, Hk2, Ldha) and a downregulation of genes involved in gluconeogenesis (G6pc, Lbp1) in cystic kidneys of Cy/+ rats compared with wild-type (+/+) rats. We then tested the effect of inhibiting glycolysis with 2-deoxyglucose (2DG) on renal functional loss and cyst progression in 5-week-old male Cy/+ rats. Treatment with 2DG (500 mg/kg/day) for 5 weeks resulted in significantly lower kidney weights (-27%) and 2-kidney/total-body-weight ratios (-20%) and decreased renal cyst index (-48%) compared with vehicle treatment. Cy/+ rats treated with 2DG also showed higher clearances of creatinine (1.98±0.67 vs 1.41±0.37 ml/min), BUN (0.69±0.26 vs 0.40±0.10 ml/min) and uric acid (0.38±0.20 vs 0.21±0.10 ml/min), and reduced albuminuria. Immunoblotting analysis of kidney tissues harvested from 2DG-treated Cy/+ rats showed increased phosphorylation of AMPK-α, a negative regulator of mTOR, and restoration of ERK signaling. Assessment of Ki-67 staining indicated that 2DG limits cyst progression through inhibition of epithelial cell proliferation. Taken together, our results show that targeting the glycolytic pathway may represent a promising therapeutic strategy to control cyst growth in PKD.
Gift of Life
From Birmingham Mail, United Kingdom
As a Birmingham police officer he is used to protecting the public - and now David Footman is preparing to help save his brother’s life.
The big-hearted Police Community Support Officer is donate a kidney to his older sibling Paul who desperately needs a transplant.
Paul, aged 39, was diagnosed with adult polycystic kidney disease 15 years ago but his condition has begun to deteriorate in recent years.
When the Birmingham chef was told that without a transplant he faced kidney failure, his brother David was quick to offer to donate one of his own kidneys in a bid to save him.
David, a dad-of-two from Kings Norton, said: “We didn’t really have a conversation, I knew he was getting worse and he needed to have this done.
“I am just grateful I am able to help. I like to make a difference as a PCSO and with it being family this was always something I was going to do.
“Hopefully, we can raise awareness of kidney disease and the importance of diagnosis.
“The force has been really supportive and I am looking forward to joining back up with the rest of the team afterwards.”
The 37-year-old will go under the knife in the next few months and said he will return to pounding the streets of Stechford and Yardley after he has had time to recuperate from the operation. [Read more]
From CBS Affiliate, Channel 2, Los Angles, CA
A Diamond Bar father has gotten a new lease on life following a life-saving kidney transplant.
CBS2’s Michele Gile says his Coast Guard family stepped up in a big day.
Frank Maggelet and Patricia Lovenstein had only met twice but she had no doubt that he — a retired Coast Guard Port security chief — would get her kidney.
“Well, first of all there was no if,” she said, “I knew that it was going to happen.”
She considers him, a husband and father, like her own family.
A decade ago, her husband was his senior officer — buddies in the Coast Guard, stationed together in Boston.
A few months ago, Lovenstein — a former nurse — read on Facebook that Maggelet needed help and was in dire need of a new kidney after he developed polycystic kidney disease.
“He still has never asked me for my kidney,” she said, with a laugh, “it’s already in him. It’s a little late for that. But he’s never asked. No one ever asked me to do this.”
The transplant took place at UCI Medical Center in Orange on Tuesday.
Her left kidney now sits in his right abdomen.
Today was the first day the two got to share a private moment without family around. He was able to whisper a “thank you” to Lovenstein, grateful that the transplant came at just the right time. He was left with a kidney that barely functioned.
He learned on Thanksgiving night that he will have many more years to spend with his wife and young daughters.
“Patricia called, and the hospital called. ‘You’re a match.’ And the four of us, Thanksgiving evening, we cried,” said Maggelet, “because it was like a miracle.”
From WKRN, ABC affiliate Channel 2, Nashville, TN
GRAND RAPIDS, Mich. (WOOD) — A Michigan man celebrated his 55th birthday Thursday with a gift from his wife he’ll likely never be able to match.
Jim Sisson suffered from polycystic kidney disease, a rare genetic disorder.
His father died from complications of the disease in the 1980s.
Sisson got on a waiting list for a new kidney, joining more than 100,000 people nationwide. He was prepared for a wait that could last years.
But it turned out a match was living under the same roof – his wife Laurie.
“We’ve been very blessed. There’s so many people out there that are not this fortunate,” Laurie Sisson said.
On Monday, the transplant team at Mercy Health Saint Mary’s hospital in Grand Rapids, Michigan took one of Laurie’s kidneys and put it inside Jim.
“He kept saying he didn’t want me to of it. He wouldn’t think any less of me if I didn’t. I said, ‘God didn’t make me a match for me to be selfish and keep the kidney to myself,’” Laurie Sisson said.
“There was never once I looked back thinking I don’t want to do this.”
Laurie’s kidney worked for her husband — in more ways than one.
“I’ve been praying for a long time that we could reignite a spark. You know, when you’re married 35 years sometimes it takes a little oomph to get things where they should be,” Laurie Sisson said.
“You’ve got to be careful what you pray for.”
If there’s one message the couple wants to get out, it’s the importance of organ donation.
In Michigan alone, the waiting list for a new kidney is longer than 2,800 people. More than 350 people are waiting for a call from Mercy Health Saint Mary’s transplant program.
Jim Sisson said he was looking at a wait of up to eight years for a new kidney.
“If I would have went to Ohio, I could have got one within a year or two maybe because they have a lot more people that signed the registered donor list,” he explained.
Thursday, just three days after receiving his new kidney, Sisson celebrated his 55th birthday. His next challenge, he said, will be coming up with a gift for his wife.
“Always wanted to go on a trip,” Laurie Sisson hinted.
“Wherever she want to go now. Who’s she kidding?” her husband said.
No comments:
Post a Comment